A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain

A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain

<i>Background and Objectives</i>: Codeine requires biotransformation by the CYP2D6 enzyme, encoded by the polymorphic <i>CYP2D6</i> gene, to morphine for therapeutic efficacy. CYP2D6 phenotypes of poor, intermediate, and ultra-rapid metabolisers are at risk of codeine non-res...

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Bibliographic Details
Main Authors: Helen Radford, Karen H. Simpson, Suzanne Rogerson, Mark I. Johnson
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Medicina
Subjects:
pain
analgesics
cytochrome P-450 <i>CYP2D6</i>
chronic pain
codeine
pharmacogenetics
pain management
Online Access:https://www.mdpi.com/1010-660X/55/6/220

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https://www.mdpi.com/1010-660X/55/6/220

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