Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6

Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6

The mechanism by which acetaminophen (APAP) causes liver damage evokes many aspects drug metabolism, oxidative chemistry, and genetic-predisposition. In this study, we leverage the relative resistance of female C57BL/6 mice to APAP-induced liver damage (AILD) compared to male C57BL/6 mice in order...

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Bibliographic Details
Main Authors: Isaac Mohar, Brendan D. Stamper, Peter M. Rademacher, Collin C. White, Sidney D. Nelson, Terrance J. Kavanagh
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Acetaminophen
Peroxiredoxin-6
Gender
Mitochondria
Glutathione
Gclm
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000238

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http://www.sciencedirect.com/science/article/pii/S2213231714000238

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