Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were...

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Bibliographic Details
Main Authors: Alerie Guzman De La Fuente, Simona Lange, Maria Elena Silva, Ginez A. Gonzalez, Herbert Tempfer, Peter van Wijngaarden, Chao Zhao, Ludovica Di Canio, Andrea Trost, Lara Bieler, Pia Zaunmair, Peter Rotheneichner, Anna O’Sullivan, Sebastien Couillard-Despres, Oihana Errea, Maarja A. Mäe, Johanna Andrae, Liqun He, Annika Keller, Luis F. Bátiz, Christer Betsholtz, Ludwig Aigner, Robin J.M. Franklin, Francisco J. Rivera
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
neurovascular niche
pericytes
remyelination
oligodendrocyte progenitor cell
Lama2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310951

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717310951

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