2,3-Dihydro-1<em>H</em>-cyclopenta[<em>b</em>]quinoline Derivatives as Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling and Biodistribution

2,3-Dihydro-1<em>H</em>-cyclopenta[<em>b</em>]quinoline Derivatives as Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling and Biodistribution

In the present study we describe the synthesis and biological assessment of new tacrine analogs in the course of inhibition of acetylcholinesterase. The obtained molecules were synthesized in a condensation reaction between activated 6-BOC-hydrazinopyridine-3-carboxylic acid and 8-aminoalkyl derivat...

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Bibliographic Details
Main Authors: Elżbieta Mikiciuk-Olasik, Magdalena Markowicz, Barbara Malawska, Marek Bajda, Milan Lázniček, Alice Lázničková, Paweł Szymański
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
biological activity
medicinal chemistry
isotopic labeling
drug design
radiopharmaceuticals
Online Access:http://www.mdpi.com/1422-0067/13/8/10067

Internet

http://www.mdpi.com/1422-0067/13/8/10067

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