Hyperforin, an anti-inflammatory constituent from St. John’s wort, inhibits microsomal prostaglandin E2 synthase-1 and suppresses prostaglandin E2 formation in vivo

Hyperforin, an anti-inflammatory constituent from St. John’s wort, inhibits microsomal prostaglandin E2 synthase-1 and suppresses prostaglandin E2 formation in vivo

The acylphloroglucinol hyperforin (Hyp) from St. John’s wort possesses anti-inflammatory and anti-carcinogenic properties which were ascribed among others to the inhibition of 5-lipoxygenase. Here, we investigated whether Hyp also interferes with prostanoid generation in biological systems, particul...

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Bibliographic Details
Main Authors: Andreas eKoeberle, Antonietta eRossi, Julia eBauer, Friederike eDehm, Luisella eVerotta, Hinnak eNorthoff, Lidia eSautebin, Oliver eWerz
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-02-01
Series:Frontiers in Pharmacology
Subjects:
Inflammation
cyclooxygenase
Hyperforin
Prostaglandin E2
St. John’s wort
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00007/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00007/full

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