Exploiting Natural Cross-reactivity between Human Immunodeficiency Virus (HIV)-1 p17 Protein and Anti-gp41 2F5 Antibody to Induce HIV-1 Neutralizing Responses In Vivo

Exploiting Natural Cross-reactivity between Human Immunodeficiency Virus (HIV)-1 p17 Protein and Anti-gp41 2F5 Antibody to Induce HIV-1 Neutralizing Responses In Vivo

Anti-p17 antibodies are able to neutralize human immunodeficiency virus (HIV) entry in a mouse model. In this study, we identified a region of sequence similarity between the epitopes of anti-p17 neutralizing antibodies and anti-gp41 neutralizing 2F5 antibody and verified cross-reactivity between p1...

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Bibliographic Details
Main Authors: Bernard Verrier, Stéphane Paul, Céline Terrat, Liza Bastide, Agathe Ensinas, Capucine Phelip, Blandine Chanut, Laura Bulens-Grassigny, Fabienne Jospin, Christophe Guillon
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus-1
gp41
p17
neutralizing antibodies
cross-reactivity
antigen engineering
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00770/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00770/full

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