Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach

Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach

Abstract Background Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the underlying regulatory processes are only partly understood. Results We assembled regulator binding information from serveral so...

Full description

Bibliographic Details
Main Authors: Alexandra M. Poos, Theresa Kordaß, Amol Kolte, Volker Ast, Marcus Oswald, Karsten Rippe, Rainer König
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Bioinformatics
Subjects:
Mixed integer linear programming
Gene regulatory networks
Transcriptional regulation
Telomere maintenance
Telomerase
Cancer
Online Access:https://doi.org/10.1186/s12859-019-3323-2

Internet

https://doi.org/10.1186/s12859-019-3323-2

Similar Items