Synthesis of N-peptide-6-amino-D-luciferin Conjugates

Synthesis of N-peptide-6-amino-D-luciferin Conjugates

A general strategy for the synthesis of N-peptide-6-amino-D-luciferin conjugates has been developed. The applicability of the strategy was demonstrated with the preparation of a known substrate, N-Z-Asp-Glu-Val-Asp-6-amino-D-luciferin (N-Z-DEVD-aLuc). N-Z-DEVD-aLuc was obtained via a hybrid liquid/s...

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Bibliographic Details
Main Authors: Anita K. Kovács, Péter Hegyes, Gábor J. Szebeni, Lajos I. Nagy, László G. Puskás, Gábor K. Tóth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
bioluminescence
aminoluciferin
conjugate
protease activity
solid-phase peptide synthesis
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00120/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00120/full

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