Transforming protein-polymer conjugate purification by tuning protein solubility
Therapeutic proteins are often conjugated with polymers, but separating the conjugate from unconjugated protein and free polymer is a major challenge. Here, the authors discover that proteins conjugated to charged or zwitterionic polymers maintain solubility in 100% ammonium sulfate, greatly simplif...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12612-9 |