Sialin expression in the CNS implicates extralysosomal function in neurons

Sialin expression in the CNS implicates extralysosomal function in neurons

SLC17A5 encodes a lysosomal membrane protein, sialin, which transports sialic acid from lysosomes. Mutations in sialin result in neurodegenerative sialic acid storage disorders, Salla disease (SD) and infantile sialic acid storage disease (ISSD). Here we analyzed sialin in mouse central nervous syst...

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Bibliographic Details
Main Authors: Nina Aula, Outi Kopra, Anu Jalanko, Leena Peltonen
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Salla disease
Lysosome
Lysosomal membrane protein
Sialin
Sialic acid transporter
In situ hybridization
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002377

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http://www.sciencedirect.com/science/article/pii/S0969996103002377

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