Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway

Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway

BackgroundHashimoto’s thyroiditis (HT) is an autoimmune disease that features activation of thyroid antigen-specific helper T cells. HT patients have increased Th1 and Th17 T cell subsets. Glycolysis supports chronic activation of Th1 and Th17 T cells, but how this contributes to HT remains unknown....

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Bibliographic Details
Main Authors: Lei Zhao, Qiong Wu, Xiaoli Wang, Shiqi Wang, Xiaoguang Shi, Zhongyan Shan, Weiping Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Endocrinology
Subjects:
Hashimoto’s thyroiditis
Tregs
HIF1a
immunometabolism
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.659738/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.659738/full

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