Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance

The 2009 pandemic influenza A virus outbreak led to the systematic use of the neuraminidase (NA) inhibitor oseltamivir (OST). Consequently, OST-resistant strains, carrying the mutation H275Y, emerged in the years after the pandemics, with a prevalence of 1-2%. Currently, OST-resistant strains have b...

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Bibliographic Details
Main Authors: Thiago Moreno Lopes e Souza, Natalia Fintelman-Rodrigues, Paola Cristina Resende, Milene Mesquita, Tatiana Schaffer Gregianini, Fernando A Bozza, Ana Carla Pecego, Sandra Bianchini Fernandes, Ana Luisa Furtado Cury, Irina Nastassja Riediger, Marilda M Siqueira
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-02-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
influenza A(H1N1)pdm09
oseltamivir
antiviral
resistance
H275Y
permissive mutation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000100101&lng=en&tlng=en

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