IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism

IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism

Insulin-degrading enzyme (IDE) was applied to catalyze hydrolysis of Nociceptin/Orphanin 1-16 (OFQ/N) to show the involvement of the enzyme in degradation of neuropeptides engaged in pain transmission. Moreover, IDE degradative action towards insulin (Ins) was inhibited by the OFQ/N fragments, sugge...

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Bibliographic Details
Main Authors: Gabriele Antonio Zingale, Francesco Bellia, Ikhlas Mohamed Mohamud Ahmed, Przemyslaw Mielczarek, Jerzy Silberring, Giuseppe Grasso
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
Insulin-degrading enzyme
nociceptin
pain threshold
diabetes
proteolytic enzyme
pain transmission
rat spinal cord
cysteine protease
metalloprotease
neuropeptide
Online Access:https://www.mdpi.com/1422-0067/20/18/4447

Internet

https://www.mdpi.com/1422-0067/20/18/4447

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