Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis

Linking Phospho-Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) to Histone Ubiquitination and Acetylation Essential for Spermatid Development During Spermiogenesis

GRTH/DDX25 is a testicular RNA helicase expressed in germ cells that plays a crucial role in completion of spermatogenesis. Previously, we demonstrated a missense mutation (R242H) of GRTH gene in Japanese infertile patients (5.8%) with non-obstructive azoospermia. This mutation upon expression in CO...

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Bibliographic Details
Main Authors: Raghuveer Kavarthapu, Rajakumar Anbazhagan, Ashish K. Sharma, Joseph Shiloach, Maria L. Dufau
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
phospho-GRTH/DDX25
spermatogenesis
round spermatids
histones
ubiquitination
acetylation
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00310/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00310/full

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