A Central Bioactive Region of LTBP-2 Stimulates the Expression of TGF-β1 in Fibroblasts via Akt and p38 Signalling Pathways

A Central Bioactive Region of LTBP-2 Stimulates the Expression of TGF-β1 in Fibroblasts via Akt and p38 Signalling Pathways

Latent transforming growth factor-β-1 binding protein-2 (LTBP-2) belongs to the LTBP-fibrillin superfamily of extracellular proteins. Unlike other LTBPs, LTBP-2 does not covalently bind transforming growth factor-β1 (TGF-β1) but appears to be implicated in the regulation of TGF-β1 bioactivity, altho...

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Bibliographic Details
Main Authors: Mohamed A. Sideek, Joshua Smith, Clementine Menz, Julian R. J. Adams, Allison J. Cowin, Mark A. Gibson
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Molecular Sciences
Subjects:
LTBP-2
TGF-β
fibroblast
p38 MAPK
Akt
fibrosis
Online Access:https://www.mdpi.com/1422-0067/18/10/2114

Internet

https://www.mdpi.com/1422-0067/18/10/2114

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