Combined proteomic and transcriptomic approaches reveal externalized keratin 8 as a potential therapeutic target involved in invasiveness of head and neck cancers

Keratin 8 (K8) expressed at the surface of cancer cells, referred as externalized K8 (eK8), has been observed in a variety of carcinoma cell lines. K8 has been previously reported to be expressed in poorly differentiated head and neck squamous cell carcinoma (HNSCC); however, its role during the inv...

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Main Authors: Marie Alexandra Albaret, Arnaud Paré, Lucie Malet, Geneviève De Souza, Emilie Lavergne, Dominique Goga, Gonzague De Pinieux, Claire Castellier, Aurélie Swalduz, Vivian Robin, Vincent Lavergne, Hichem-Claude Mertani, Isabelle Treilleux, Claudine Vermot-Desroches, Jean-Jacques Diaz, Pierre Saintigny
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320303703