Clinical, Immunological, and Molecular Features of Typical and Atypical Severe Combined Immunodeficiency: Report of the Italian Primary Immunodeficiency Network

Clinical, Immunological, and Molecular Features of Typical and Atypical Severe Combined Immunodeficiency: Report of the Italian Primary Immunodeficiency Network

Severe combined immunodeficiencies (SCIDs) are a group of inborn errors of the immune system, usually associated with severe or life-threatening infections. Due to the variability of clinical phenotypes, the diagnostic complexity and the heterogeneity of the genetic basis, they are often difficult t...

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Main Authors: Emilia Cirillo, Caterina Cancrini, Chiara Azzari, Silvana Martino, Baldassarre Martire, Andrea Pession, Alberto Tommasini, Samuele Naviglio, Andrea Finocchi, Rita Consolini, Paolo Pierani, Irene D'Alba, Maria Caterina Putti, Antonio Marzollo, Giuliana Giardino, Rosaria Prencipe, Federica Esposito, Fiorentino Grasso, Alessia Scarselli, Gigliola Di Matteo, Enrico Attardi, Silvia Ricci, Davide Montin, Fernando Specchia, Federica Barzaghi, Maria Pia Cicalese, Giuseppe Quaremba, Vassilios Lougaris, Silvia Giliani, Franco Locatelli, Paolo Rossi, Alessandro Aiuti, Raffaele Badolato, Alessandro Plebani, Claudio Pignata
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
primary immunodeficiencies
severe combined immunodeficiencies
atypical SCID
T-cell defects
lymphopenia
Omenn syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01908/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01908/full

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