An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.

An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.

BACKGROUND: Integrase (IN) of the type 1 human immunodeficiency virus (HIV-1) catalyzes the integration of viral DNA into host cellular DNA. We identified a bi-helix motif (residues 149-186) in the crystal structure of the catalytic core (CC) of the IN-Phe185Lys variant that consists of the alpha(4)...

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Bibliographic Details
Main Authors: Hayate Merad, Horea Porumb, Loussiné Zargarian, Brigitte René, Zeina Hobaika, Richard G Maroun, Olivier Mauffret, Serge Fermandjian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2607020?pdf=render

Internet

http://europepmc.org/articles/PMC2607020?pdf=render

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