Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay

Determination of lesinurad in rat plasma by a UHPLC–MS/MS assay

Abstract Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with refractory gout. In the present study, a sensitive...

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Bibliographic Details
Main Authors: Xiao-Yang Zhou, Ling-Jing Yuan, Zhe Chen, Peng-Fei Tang, Xiang-Yu Li, Guo-Xin Hu, Jian-Ping Cai
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Chemistry Central Journal
Subjects:
Lesinurad
UHPLC–MS/MS
Rat plasma
Pharmacokinetics
Online Access:http://link.springer.com/article/10.1186/s13065-017-0353-6

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http://link.springer.com/article/10.1186/s13065-017-0353-6

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