Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers

Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers

Alzheimer’s disease is one of the most common chronic neurodegenerative disorders. Despite several in vivo and clinical studies, the cause of the disease is poorly understood. Currently, amyloid β (Aβ) peptide and its tendency to assemble into soluble oligomers are known...

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Bibliographic Details
Main Authors: Éva Bartus, Gábor Olajos, Ildikó Schuster, Zsolt Bozsó, Mária A. Deli, Szilvia Veszelka, Fruzsina R. Walter, Zsolt Datki, Zsolt Szakonyi, Tamás A. Martinek, Livia Fülöp
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
amyloid β
molecular recognition
foldamer
protein aggregation
multivalency
Online Access:http://www.mdpi.com/1420-3049/23/10/2523

Internet

http://www.mdpi.com/1420-3049/23/10/2523

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