The critical role of IL-15-PI3K-mTOR pathway in Natural Killer cell effector functions

The critical role of IL-15-PI3K-mTOR pathway in Natural Killer cell effector functions

Natural killer (NK) cells were so named for their uniqueness in killing certain tumor and virus-infected cells without prior sensitization. Their functions are modulated in vivo by several soluble immune mediators; IL-15 being the most potent among them in enabling NK cell homeostasis, maturation an...

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Bibliographic Details
Main Authors: Neethi eNandagopal, Alaa Kassim Ali, Amandeep Kaur Komal, Seung-Hwan eLee
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Immunology
Subjects:
Cytokines
Signal Transduction
Natural Killer cells
IL-15
mTOR pathway
JAK/STAT signaling pathway
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00187/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00187/full

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