Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways

Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways

Vascular networks form, remodel and mature under the influence of multiple signals of mechanical or chemical nature. How endothelial cells read and interpret these signals, and how they integrate information when they are exposed to both simultaneously is poorly understood. Here, we show using flow-...

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Bibliographic Details
Main Authors: Anne-Clémence Vion, Tijana Perovic, Charlie Petit, Irene Hollfinger, Eireen Bartels-Klein, Emmanuelle Frampton, Emma Gordon, Lena Claesson-Welsh, Holger Gerhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
endothelial cell
shear stress
VEGF
blood flow
signaling/signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.623769/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.623769/full

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