Alarmins in Osteoporosis, RAGE, IL-1, and IL-33 Pathways: A Literature Review

Alarmins are endogenous mediators released by cells following insults or cell death to alert the host’s innate immune system of a situation of danger or harm. Many of these, such as high-mobility group box-1 and 2 (HMGB1, HMGB2) and S100 (calgranulin proteins), act through RAGE (receptor f...

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Bibliographic Details
Main Authors: Massimo De Martinis, Lia Ginaldi, Maria Maddalena Sirufo, Giovanni Pioggia, Gioacchino Calapai, Sebastiano Gangemi, Carmen Mannucci
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Medicina
Subjects:
Online Access:https://www.mdpi.com/1010-660X/56/3/138