The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

Abstract Background Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. Methods Here, we performed an analysis of 42 MM samples from 21 patients by usin...

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Bibliographic Details
Main Authors: Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Medicine
Subjects:
Multiple myeloma
Disordered DNA methylation
Epipolymorphism
Epiallele switching
Inter- and intrapatient heterogeneity
Transcriptomic variability
Online Access:https://doi.org/10.1186/s13073-021-00938-3

Internet

https://doi.org/10.1186/s13073-021-00938-3

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