Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration

Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration

Cdk5 is essential for neuronal differentiation processes in the brain. Activation of Cdk5 requires the association with the mostly neuron-specific p35 or p39. Overactivation of CDK5 by cleavage of p35 into p25 is thought to be involved in neurodegenerative processes. Here, we have tested an approach...

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Bibliographic Details
Main Authors: Jan Liman, Jochen H. Weishaupt, Mathias Bähr, Gunnar P.H. Dietz
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Pharmaceuticals
Subjects:
Cdk5
Tat-technique
neurodegenerative diseases
Online Access:http://www.mdpi.com/1424-8247/3/4/1232/

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http://www.mdpi.com/1424-8247/3/4/1232/

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