Optimal Design for Estimating Parameters of the 4-Parameter Hill Model

Many drug concentration-effect relationships are described by nonlinear sigmoid models. The 4-parameter Hill model, which belongs to this class, is commonly used. An experimental design is essential to accurately estimate the parameters of the model. In this report we investigate properties of D-opt...

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Bibliographic Details
Main Authors: Leonid A. Khinkis, Laurence Levasseur, Hélène Faessel, William R. Greco
Format: Article
Language:English
Published: SAGE Publishing 2003-07-01
Series:Dose-Response
Online Access:https://doi.org/10.1080/15401420390249925

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