Evaluating the Efficacy of Taurodeoxycholic Acid in Providing Otoprotection Using an in vitro Model of Electrode Insertion Trauma

Evaluating the Efficacy of Taurodeoxycholic Acid in Providing Otoprotection Using an in vitro Model of Electrode Insertion Trauma

Cochlear implants (CIs) are widely used to provide auditory rehabilitation to individuals having severe to profound sensorineural hearing loss (SNHL). However, insertion of electrode leads to inner trauma and activation of inflammatory and apoptotic signaling cascades resulting in loss of residual h...

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Bibliographic Details
Main Authors: Viraj Shah, Rahul Mittal, David Shahal, Priyanka Sinha, Erdogan Bulut, Jeenu Mittal, Adrien A. Eshraghi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlear implant
taurodeoxycholic acid
electrode insertion trauma
oxidative stress
caspase-3 pathway
nitric oxide
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00113/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00113/full

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