Goniolactone C, a Styryl Lactone Derivative, Inhibits PDGF-BB-Induced Vascular Smooth Muscle Cell Migration and Proliferation via PDGFR/ERK Signaling

Goniolactone C, a Styryl Lactone Derivative, Inhibits PDGF-BB-Induced Vascular Smooth Muscle Cell Migration and Proliferation via PDGFR/ERK Signaling

Platelet-derived growth factor-BB (PDGF-BB) and its downstream effector, extracellular signal-regulated kinase 1/2 (ERK1/2) MAP kinase, initiate a multitude of biological effects, including vascular smooth muscle cell (VSMC) proliferation and migration, which are critical events in the initiation an...

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Bibliographic Details
Main Authors: Lan Sun, Rui Zhao, Xi Lan, Ruoyun Chen, Si Wang, Guanhua Du
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
styryl lactones
goniolactone C
VSMC
proliferation
migration
PDGF-BB
Online Access:http://www.mdpi.com/1420-3049/19/12/19501

Internet

http://www.mdpi.com/1420-3049/19/12/19501

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