Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event.

Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event.

BACKGROUND: To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. METHODOLOGY/PRINCIPAL FINDINGS: To address intertumoral heterogeneity we investigated non-microdissected tumor tissue of 106 gliomas representing 51 recurrent tumor...

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Main Authors: Ulrike Lass, Astrid Nümann, Kajetan von Eckardstein, Jürgen Kiwit, Florian Stockhammer, Jörn A Horaczek, Julian Veelken, Christel Herold-Mende, Judith Jeuken, Andreas von Deimling, Wolf Mueller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3402513?pdf=render

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http://europepmc.org/articles/PMC3402513?pdf=render

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