Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas

Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas

Abstract INTRODUCTION: Benznidazole (BZL) and Nifurtimox (NFX) are the pharmacological treatment for acute phase Chagas Disease (CD); however, therapy resistance and residual mortality development remain important unresolved issues. Posaconazole (POS) has shown a trypanocidal effect in vivo and in...

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Main Authors: Luis Eduardo Echeverría, Clara Isabel González, Julio Cesar Mantilla Hernandez, Martha Lucia Díaz, Javier Eduardo Nieto, Luis Alberto López-Romero, Julián David Rivera, Edwin Uriel Suárez, Sergio Alejandro Gómez Ochoa, Lyda Z. Rojas, Carlos A. Morillo
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT)
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
wistar rats
chagas disease
trypanocidal
benznidazole and posaconazole
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100307&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100307&lng=en&tlng=en

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