Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells

In guinea pig single ileal smooth muscle cells held under voltage-clamp, the role of phospholipase C (PLC) in activation of the muscarinic receptor-operated cationic current (Icat) was studied. U73122, a PLC inhibitor, prevented the generation of Icat by the muscarinic agonist carbachol. The effect...

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Bibliographic Details
Main Authors: Hiroyuki Okamoto, Toshihiro Unno, Daisuke Arima, Maki Suzuki, Hai-Dun Yan, Hayato Matsuyama, Masakazu Nishimura, Seiichi Komori
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319324387