TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The downstream in vivo cellular effects of thi...

Full description

Bibliographic Details
Main Authors: Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers, Anna King
Format: Article
Language:English
Published: The Company of Biologists 2021-02-01
Series:Disease Models & Mechanisms
Subjects:
tdp-43
amyotrophic lateral sclerosis
frontotemporal lobar degeneration
neurodegeneration
disease model
visual system
Online Access:http://dmm.biologists.org/content/14/2/dmm047548

Internet

http://dmm.biologists.org/content/14/2/dmm047548

Similar Items