Longitudinal Monitoring of EGFR and PIK3CA Mutations by Saliva-Based EFIRM in Advanced NSCLC Patients With Local Ablative Therapy and Osimertinib Treatment: Two Case Reports

Longitudinal Monitoring of EGFR and PIK3CA Mutations by Saliva-Based EFIRM in Advanced NSCLC Patients With Local Ablative Therapy and Osimertinib Treatment: Two Case Reports

Background: The longitudinal monitoring of actionable oncogenes in circulating tumor DNA (ctDNA) of non-small cell lung cancer (NSCLC) is crucial for clinicians to evaluate current therapeutic response and adjust therapeutic strategies. Saliva-based electric field–induced release and measurement (EF...

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Bibliographic Details
Main Authors: Ning Li, Udayan Guha, Chul Kim, Leah Ye, Jordan Cheng, Feng Li, David Chia, Fang Wei, David T. W. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
osimertinib
local ablative therapy
gene mutation
acquired resistance
liquid biopsy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01240/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01240/full

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