Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells
Abstract Background Prostaglandin E2 (PGE2) is an endogenous lipid mediator of inflammation. Its production is regulated by the rate-limiting upstream enzyme cyclooxygenase-2 (COX-2). We have recently demonstrated that the major cell type expressing COX-2 in the germinal center is follicular dendrit...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-04-01
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Series: | BMC Immunology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12865-020-00347-y |