The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of...

Full description

Bibliographic Details
Main Authors: Fatma M. Ghoneim, Hani Alrefai, Ayman Z. Elsamanoudy, Salwa M. Abo El-khair, Hanaa A. Khalaf
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Biology
Subjects:
valproic acid
alpha lipoic acid
pancreas
nrf2
bcl-2
caspase-3
Online Access:https://www.mdpi.com/2079-7737/9/9/239

Internet

https://www.mdpi.com/2079-7737/9/9/239

Similar Items