Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo

Zoledronate Causes a Systemic Shift of Macrophage Polarization towards M1 In Vivo

Background: Immunomodulatory properties of bisphosphonates (BP) are suggested to contribute to the development of medication-associated osteonecrosis of the jaw (MRONJ). Furthermore, bisphosphonate-derived immune modulation might contribute to the anti-metastatic effect observed in breast cancer pat...

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Bibliographic Details
Main Authors: Manuel Weber, Andi Homm, Stefan Müller, Silke Frey, Kerstin Amann, Jutta Ries, Carol Geppert, Raimund Preidl, Tobias Möst, Peer W. Kämmerer, Marco Kesting, Falk Wehrhan
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
bisphosphonate
Zoledronate
antiresorptives
macrophage polarization
M1
M2
Online Access:https://www.mdpi.com/1422-0067/22/3/1323

Internet

https://www.mdpi.com/1422-0067/22/3/1323

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