The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression

The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression

Regressing tumors are usually associated with a large immune infiltrate, but the molecular and cellular interactions that govern a successful anti-tumor immunity remain elusive. Here, we have triggered type I Interferon (IFN) signaling in a breast tumor model (MMTV-PyMT) using 5,6-dimethylxanthenone...

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Bibliographic Details
Main Authors: Julia M. Weiss, Marion V. Guérin, Fabienne Regnier, Gilles Renault, Isabelle Galy-Fauroux, Lene Vimeux, Vincent Feuillet, Elisa Peranzoni, Maxime Thoreau, Alain Trautmann, Nadège Bercovici
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
cooperation
imaging
interferon
myeloid cells
sting
tumor regression
t lymphocytes
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1346765

Internet

http://dx.doi.org/10.1080/2162402X.2017.1346765

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