Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats

Abstract Background Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoagulability. We aimed at determining whether recombinant human thrombomo...

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Bibliographic Details
Main Authors: Julie Helms, Raphaël Clere-Jehl, Elsa Bianchini, Pierrick Le Borgne, Mélanie Burban, Fatiha Zobairi, Jean-Luc Diehl, Lelia Grunebaum, Florence Toti, Ferhat Meziani, Delphine Borgel
Format: Article
Language:English
Published: SpringerOpen 2017-12-01
Series:Annals of Intensive Care
Subjects:
DIC
Immunothrombosis
Microvesicles
NETosis
Septic shock
Online Access:http://link.springer.com/article/10.1186/s13613-017-0340-z

Internet

http://link.springer.com/article/10.1186/s13613-017-0340-z

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