Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.

Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.

Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating event in the cascade leading to tau toxicity and neur...

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Bibliographic Details
Main Authors: Gregory M Dillon, Jaclyn L Henderson, Channa Bao, John A Joyce, Michael Calhoun, Brenda Amaral, Kristopher W King, Bekim Bajrami, Dania Rabah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228771

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https://doi.org/10.1371/journal.pone.0228771

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