The Interferon-signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases

The Interferon-signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases

Innate immune responses direct the nature and specificity of downstream adaptive responses in autoimmune diseases. One of the strongest markers of innate immunity is the up-regulated expression of interferon (IFN) and IFN-responsive/stimulated genes (IRGs/ISGs). While multiple IRGs are induced durin...

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Bibliographic Details
Main Authors: Cuong eNguyen, Ammon B. Peck
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Immunology
Subjects:
Gene Expression Profiling
Interferons
Animal Models
biomarkers
Human Disease
sjogren syndrome
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00142/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00142/full

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