Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2

Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2

We provide a theory for employing Förster resonance energy transfer (FRET) measurements to determine altered heteropentameric ion channel stoichiometries in intracellular compartments of living cells. We simulate FRET within nicotinic receptors (nAChRs) whose α4 and β2 subunits contain acceptor and...

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Bibliographic Details
Main Authors: Dennis A. Dougherty, Henry A. Lester, Fraser J. Moss, Crystal Dilworth, Christopher I. Richards, Rahul Srinivasan
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
nicotine
cytisine
NFRET
nicotine addiction
Parkinson’s disease
ion channels
Online Access:http://www.mdpi.com/1422-0067/13/8/10022

Internet

http://www.mdpi.com/1422-0067/13/8/10022

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