Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis.

Francisella tularensis is a highly infectious bacterium causing the zoonotic disease tularemia. Its ability to multiply and survive in macrophages is critical for its virulence. By screening a bank of HimarFT transposon mutants of the F. tularensis live vaccine strain (LVS) to isolate intracellular...

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Bibliographic Details
Main Authors: Khaled Alkhuder, Karin L Meibom, Iharilalao Dubail, Marion Dupuis, Alain Charbit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2629122?pdf=render