A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is ass...

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Bibliographic Details
Main Authors: Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P. Hanger
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Tauopathy
Microtubule binding
Akt
Glycogen synthase kinase-3
Insulin
Online Access:http://link.springer.com/article/10.1186/s40478-018-0651-9

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http://link.springer.com/article/10.1186/s40478-018-0651-9

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