TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model

ABSTRACT: Background: Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of new therapies. The Mutt homolog 1 (MTH1)...

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Main Authors: Brice Moukengue, Hannah K Brown, Céline Charrier, Séverine Battaglia, Marc Baud'huin, Thibaut Quillard, Therese M Pham, Ioannis S Pateras, Vassilis G Gorgoulis, Thomas Helleday, Dominique Heymann, Ulrika Warpman Berglund, Benjamin Ory, Francois Lamoureux
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420300797

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http://www.sciencedirect.com/science/article/pii/S2352396420300797

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