Novel Multiplex Droplet Digital PCR Assays to Monitor Minimal Residual Disease in Chronic Myeloid Leukemia Patients Showing Atypical <i>BCR-ABL1</i> Transcripts

Novel Multiplex Droplet Digital PCR Assays to Monitor Minimal Residual Disease in Chronic Myeloid Leukemia Patients Showing Atypical <i>BCR-ABL1</i> Transcripts

<i>BCR-ABL1</i> fusion transcript is the minimal residual disease marker in chronic myeloid leukemia; 2% of patients show unusual breakpoints generating atypical transcripts, not quantifiable by standardized real-time PCR (RT–PCR). Response monitoring is performed by non-quantitative NES...

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Bibliographic Details
Main Authors: Jessica Petiti, Marco Lo Iacono, Matteo Dragani, Lucrezia Pironi, Cristina Fantino, Maria Cristina Rapanotti, Fabrizio Quarantelli, Barbara Izzo, Mariadomenica Divona, Giovanna Rege-Cambrin, Giuseppe Saglio, Enrico Marco Gottardi, Daniela Cilloni, Carmen Fava
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Journal of Clinical Medicine
Subjects:
chronic myeloid leukemia
<i>BCR–ABL1</i>
atypical transcripts
MRD monitoring
treatment-free remission
digital PCR
Online Access:https://www.mdpi.com/2077-0383/9/5/1457

Internet

https://www.mdpi.com/2077-0383/9/5/1457

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