Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway

Although the role of Yes-associated protein (Yap) has been described in the progression of lung cancer, the downstream effector of the Yap-Hippo pathway has not been identified. Accordingly, the aim of our study is to explore whether Yap modulates the activity of lung cancer by controlling mitochond...

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Bibliographic Details
Main Authors: Jiayu Zhou, Shizhen Zhang, Zhijun Li, Zhoumiao Chen, Yong Xu, Weiwen Ye, Zhengfu He
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
JNK
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219303373