Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data

Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data

Abstract Background The traditional approach to studying the epigenetic mechanism CpG methylation in tissue samples is to identify regions of concordant differential methylation spanning multiple CpG sites (differentially methylated regions). Variation limited to single or small numbers of CpGs has...

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Bibliographic Details
Main Authors: C. Anthony Scott, Jack D. Duryea, Harry MacKay, Maria S. Baker, Eleonora Laritsky, Chathura J. Gunasekara, Cristian Coarfa, Robert A. Waterland
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Biology
Subjects:
DNA methylation
Read-level
WGBS
Imputation
Machine learning
Random forests
Online Access:http://link.springer.com/article/10.1186/s13059-020-02065-5

Internet

http://link.springer.com/article/10.1186/s13059-020-02065-5

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