Gene Expression Levels of the Prolyl Hydroxylase Domain Proteins <i>PHD1</i> and <i>PHD2</i> but Not <i>PHD3</i> Are Decreased in Primary Tumours and Correlate with Poor Prognosis of Patients with Surgically Resected Non-Small-Cell Lung Cancer

Gene Expression Levels of the Prolyl Hydroxylase Domain Proteins <i>PHD1</i> and <i>PHD2</i> but Not <i>PHD3</i> Are Decreased in Primary Tumours and Correlate with Poor Prognosis of Patients with Surgically Resected Non-Small-Cell Lung Cancer

Background: Hypoxia correlates with poor prognosis in several cancer types, including lung cancer. Prolyl hydroxylase domain proteins (PHDs) play a role in cell oxygen sensing, negatively regulating the hypoxia-inducible factor (HIF) pathway. Our study aim was to evaluate <i>PHD1</i>, &l...

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Bibliographic Details
Main Authors: Ana Koren, Matija Rijavec, Tomaž Krumpestar, Izidor Kern, Aleksander Sadikov, Tanja Čufer, Peter Korošec
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
non-small-cell lung cancer
prolyl hydroxylase domain proteins
mRNA expression
prognosis
Online Access:https://www.mdpi.com/2072-6694/13/10/2309

Internet

https://www.mdpi.com/2072-6694/13/10/2309

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