Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure

<p>Abstract</p> <p>Background</p> <p>Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models assume the statistical independence of each position in the sequen...

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Bibliographic Details
Main Authors: Webb-Robertson Bobbie-Jo, Bystroff Christopher
Format: Article
Language:English
Published: BMC 2008-10-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/9/429