Drug-transporter mediated interactions between anthelminthic and antiretroviral drugs across the Caco-2 cell monolayers

Drug-transporter mediated interactions between anthelminthic and antiretroviral drugs across the Caco-2 cell monolayers

Abstract Background Drug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a transwell. The impact of anthelminthics on the transport of ARVs was dete...

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Bibliographic Details
Main Authors: Gabriel Kigen, Geoffrey Edwards
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Antiretroviral
Antiparasitic
Drug interactions
Caco-2 cell monolayers
Drug transport
Intestinal epithelium
Online Access:http://link.springer.com/article/10.1186/s40360-017-0129-6

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http://link.springer.com/article/10.1186/s40360-017-0129-6

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